Ji Yun Ahn, Suna Kim, Sung Eun Jung, Tae Youl Ha
Abstract
Alzheimer’s disease is characterized by neuronal loss and the presence of extracellular senile plaques whose major constituent is amyloid-β peptide (Aβ). In this study, we investigated the effects of a water extract of licorice (Glycyrrhiza uralensis F.) (GWE) on Aβ25-35-induced apoptosis in PC12 cells. Exposure to Aβ25-35-induced apoptosis, such as decreased mitochondrial transmembrane potential, increased lipid peroxide formation, decreased antiapoptotic bcl-2 and poly(ADP-ribose) polymerase, and elevated proapoptotic bax, and caspase-3. However, treatment of GWE effectively decreased cell deaths evoked by Aβ25-35. This result suggests that GWE exerts protective effect against apoptotic neuronal cell death induced by Aβ fragments.
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