Geonuk Jeon, Youngmin Choi, Seon-Mi Lee, Younghwa Kim, Heon-Sang Jeong, Junsoo Lee
Abstract
Anti-adipogenesis activity of methanol extract from hot pepper (Capsicum annuum L.) seeds (PSE) was evaluated. Exposure to PSE (25–200 μg/mL) for a 72 hr incubation period did not alter cell viability compared to the control. The adipocyte treated with PSE at the concentration of 200, 100, and 50 μg/mL showed decreased color intensity as compared to the control suggesting decreased lipid accumulation in the adipocyte. Moreover, the glycerol-3-phosphate dehydrogenase activity was significantly reduced. The expression of C/EBPβ, C/EBPα, and PPARγ, important adipogenic transcription factors, was significantly reduced when PSE was added to cells from day 0 to 6 as compared with the control group. The results suggest that PSE has significant health-promoting effects, having excellent anti-obesity activities.
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