Donghyuck Bae, Yanghee You, Ho-Geun Yoon, Kyungmi Kim, Yoo-Hyun Lee, Yongjae Kim, Humyoung Baek, Sunoh Kim, Jeongmin Lee, Woojin Jun
Abstract
Hepatoprotective effects of loquat (Eriobotrya japonica) leaves were investigated in HepG2 cells overexpressing CYP2E1. When compared to cells treated with 200 mM ethanol alone, a concentration-dependent increase in cell viability was observed in the cells pretreated with 40 and 80 μg/mL of 5% ethanol extract (EJE) of loquat leaves (23 and 36%, respectively). Also, pretreatment with EJE lead to a decrease in intracellular reactive oxygen species formation and an increase in hepatic antioxidant activity. These results suggest that EJE attenuates oxidative stress by improving antioxidative potentials, which contribute to this herb’s protective profile against ethanol-induced toxicity in vitro.
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