Inhibitory effect of ginsenosides from ginseng leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells

Nguyen Huu Tung, Seok Bean Song, Gyu Yong Song, Jeong-Ah Kim, Jung-Eun Koo, Hee-Kyoung Kang, Young-Sang Koh, Young Ho Kim

                                                                                    

Abstract

Ginseng leaves and flowers have been known to be rich in various ginsenosides. The aim of present study is to screen the effect of 34 ginsenosides from ginseng leaves and flowers on interlukin (IL)-12 production in bone marrow-derived dendritic cells induced by lipopolysaccharide (LPS). Noticeably, floralginsenoside Kc (5), floralginsenoside J (26), and ginsenoside I (33) exhibited particularly inhibitory effect on LPS-induced IL-12 production with IC₅₀ values of 16.3, 25.8, and 6.7 μM, respectively. In addition, floralginsenoside Kc (5) suppressed significantly LPS-stimulated IL-6 and tumor necrosis factor-α (TNF-α) production. These results warrant further studies concerning potential of saponin extracts of Panax ginseng leaves and flowers for medicinal foods.

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Keywords :interleukin-12 ,Panax ginseng ,ginsenoside ,bone marrow-derived dendritic cell.