Chunmei Li, Hee Jeong Son, Chaoqing Huang, Seok Ki Lee, Jayant Lohakare, Myeong-Hyeon Wang
Abstract
Two different species of hawthorn, Crataegus pinnatifida Bunge var. typica Schneider (CBS) andCrataegus pinnatifida Bunge (CB) are traditional medicinal plants, which belong to the Crataegusgenus of the Rosaceae family. In this study, the antioxidant, anti-α-glucosidase, and anti-inflammatory activities of CBS and CB methanolic extracts were measured. The CB extract showed significantly higher antioxidant activity than CBS extract by several antioxidants properties. Anti-diabetes activity was expressed as α-glucosidase inhibits activity, both extracts showed very low anti-diabetes activity. Furthermore, the inhibitory activity on lipopolysaccharide (LPS) induced nitric oxide (NO) production and pro-inflammatory iNOS and COX-2 mRNA levels were measured. The CBS extract exhibited stronger anti-inflammatory activity than CB extract. Compared the present findings of 2 kinds of Crataegus species, the CB is more suitable for further anti-oxidative research. However, the CBS can potentially be developed into products for the prevention of inflammatory related diseases.
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