Deok-Seon Ryu, Seon-Hee Kim, Seung-Min Oh, Hyeong-Seon Lee, Jae-Han Jeong, Soo-Hwan Kim, Dong-Seok Lee
Abstract
In this study, we investigated the immunosuppressive effects of water-soluble barley β-glucan (BP) in mouse immune cells. The BP was prepared from barley (Hordeum vulgare), and it suppressed the proliferation of splenocytes stimulated with concanavalin A (Con A), interleukin-2 (IL-2), and alloantigenic splenocytes in a dose-dependent manner (0.25, 0.5, and 1mg/mL). Furthermore, the death-inducing activities of cytotoxic T lymphocytes (CTLs) and lymphokine-activated killer cells (LAKs) in alloantigen-reactive splenocytes were significantly suppressed by more than 50%. Also, the production of IL-2 in the splenocytes decreased. These results suggest that these barley-originated polysaccharides can be used as potential immunosuppressive agents.
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