Tae Kyun Kim, Dongsun Park, Seongho Yeon, Sun Hee Lee, Young Jin Choi, Dae-Kwon Bae, Yun-Hui Yang, Goeun Yang, Seong Soo Joo, Woo-Taek Lim, Jeong-Yong Lee, Joon-Soo Lee, Heon-Sang Jeong, Seock-Yeon Hwang, Yun-Bae Kim
Abstract
Physical function-improving effects of a silk amino acid preparation (SAA) in Parkinson’s disease (PD) model rats were investigated. 6-Hydroxydopamine (6-OHDA, 8 μg)+ascorbic acid (0.6 μg) was injected into right medial forebrain bundle of 8-week-old Sprague-Dawley rats to induce PD, and SAA (50, 160, or 500 mg/kg) was orally administered for 30 days. On day 15 and 30, behavioral abnormalities, neuronal loss, and dopamine and its metabolites were analyzed. Injection of 6-OHDA impaired pole test performances, which were markedly improved by treatment with SAA. Increased using rate of ipsilateral (normal) forelimb in cyclinder test and apomorphine (0.05 mg/kg)-induced circling behavior of PD rats were remarkably corrected by the compounds. In addition, 6-OHDA-induced loss of neurons as well as decreases in dopamine and its metabolites were significantly attenuated by SAA. The results indicate that SAA preserves movement function of PD model animals by protecting dopamine neurons against 6-OHDA neurotoxicity.
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