Phenolic components from the leaves of Panax ginseng and their effects on HL-60 human leukemia cells

Nguyen Huu Tung, Jeong-Hyun Son, Kyoungwon Cho, Jeong-Ah Kim, Jae-Hee Hyun, Hee-Kyoung Kang, Gyu Yong Song, Chun Jung Park, Young Ho Kim

                                                                                               

Abstract

This study investigates phenolic components from the Panax ginseng C.A. Meyer leaves led to the isolation of 3 flavonoids (1–3). Their structures were characterized on the basis of physicochemical properties, nuclear magnetic resonance (NMR) spectra, electron spray ionization-mass spectrometry (ESI-MS) data, and comparison with those in the literature. Of them, sophoraflavonoloside (2) and prunin (3) were found to inhibit the growth of HL-60 human leukemia cells with IC₅₀ in values of 29.8 and 21.4 μM by the induction of apoptosis.

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Keywords:Panax ginseng,Araliaceae,flavonoid,cytotoxic activity,HL-60 cell,apoptosis.